The Powell Center for Women's Health is committed to working with communities to increase the number of women and people of color who participate in clinical trials. By participating in clinical trials, we can improve our health and find new treatments that work.
For more information on active clinical trials, please visit the links below, the Academic Health Center website at www.ahc.umn.edu/trials or the Fairview Health Services website at www.fairview.org/Research/
For further information on people of color and clinical trials, we also recommend the website of the Association of Black Cardiologists at http://www.abcardio.org/trials.htm.
Energy Conservation Course for Persons with Fibromyalgia or Chronic Fatigue Syndrome.
Learn how to manage your fatigue. University of Minnesota Researchers in the Program for Occupational Therapy are seeking adult participants for a study evaluating the effects of a six-week energy conservation course for persons with Fibromyalgia or Chronic Fatigue Syndrome. You may be eligible if your fatigue is serious enough to have a negative impact on your daily life and function. This course is free for all participants of the study. For more information, please contact Stephanie at 715-475-9788, or olso3637@umn.edu, or contact Dr. Virgil Mathiowetz at 612-626-3759.
Cholesterol Management in Vascular Disease
University of Minnesota researchers are seeking participants for a study comparing how two different FDA-approved cholesterol medications may reduce risk of heart attack, stroke, and other heart-related complications in individuals with vascular disease. All participants will receive a medication that targets LDL (“bad”) cholesterol. Half of the participants will also receive a medication that raises HDL (“good”) cholesterol. Study visits are conducted at a St. Paul clinic. You may be eligible if you are 45 years old or older; have a history of vascular disease such as heart attack, stroke, or significantly blocked arteries leading to the heart, brain, or legs; and have low HDL (“good”) cholesterol (approximately 53 mg/dL or less for women and 42 mg/dL or less for men).
Contact: Ellen at dodd0039@umn.edu or 651-771-0117, or visit the AIM-HIGH website at http://aimhigh-heart.com.
Menstrual Phase and Depression Symptoms in Acute Smoking Abstinence
Female smokers ages 18 to 40, with or with out depression symptoms, are wanted for an outpatient research study of the effects of menstrual cycle on short-term quitting. Participants will be paid.
Contact: 612-627-4902
Physical Activity Intervention for Smoking Cessation in Women ages 50 and Over
Female smokers, ages 50 and over are wanted for an outpatient research study of the effect of physical activity on quitting smoking. Participants will be paid.
Contact: 612-741-6426
Manage Your Health One Step at a Time
If you have diabetes mellitus and leg discomfort, you may have peripheral arterial disease. Step forward and learn more about enrolling in a take-charge clinical trial. Funded by American Diabetes Association and conducted by Dr. Tracie Collins, University of Minnesota researcher, the clinical trial involves a self-managed walking program and/or health awareness counseling. Participants commit for 6 months to learn more about the disease, gain risk-factor management skills, and improve diabetes control.
Call 612-884-0853 for more information.
Binge Eating & Obesity Research
These are paid research studies at the University of Minnesota. One study involves evaluation, dietary histories, and metabolic testing, but not treatment. Another study involves evaluation and brain scanning (MRI), but not treatment. Participants must be female aged 18-45 years of age and are over weight and/or binge eat.
Contact Information: 612-626-7926.
Brain Correlates of Affect Regulation in Borderline Personality Disorder
The University of Minnesota’s Department of Psychiatry is conducting a brain imaging research study of emotional response to facial expressions in women with borderline personality disorder. The study involves an interview assessment session lasting approximately 3-3.5 hours. An MRI scan will be scheduled on a separate visit. This is NOT a treatment study. Participants must be female, ages 18-45. A phone screen is conducted to determine eligibility. Subjects will receive $25 compensation for each visit. Parking is provided.
Contact: Nathalie, 612-626-9520
Dietary Fat Study
Healthy postmenopausal women needed for a long term feeding study of the effect of dietary fat and fatty acids on breast cancer risk reduction. All food will be provided for 3 eight-week periods. Periodic blood and urine samples will be collected. Subjects must be female, ages 45-70, who are not taking fish oil or flax supplements or any prescription medications.
Contact: 612-626-5159
Keishi Bukuryo Gan for Post-Menopausal Hot Flash Management
This study tests to see if TU 025 Keishi Bukuryo Gan reduces the frequency and severity of hot flashes in post-menopausal American women. This study will also estimate the best dose amount and determine the common short-term side effects and risks. Interested subjects must be post-menopausal women aged 45-58 with an adequate hot flash frequency severity score.
Contact: Gregory A Plotnikoff, MD 612-625-8487 or tu025@hotmail.com
Interactions Between Progesterone and Cocaine
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high. The purpose of this study is to determine whether administered progesterone reduces subjective and physiological responses to cocaine in cocaine dependent individuals. Participants must be 18-46 years old and smoked at least 1 gram of cocaine each week for the 6 months prior to study entry.
Contact: Sheila M. Specker, MD 612-273-9806 or speck001@tc.umn.edu
Treatment of Smokeless Tobacco Users Comparison across treatment conditions
We are looking for participants in a research study that examines different ways of controlling your tobacco use and to help you quit. In this study, we will help you address your tobacco use by providing behavioral counseling and a product. If you participate, you will attend 6-7 visits and one phone call over the next 6-7 months. Your last visit will be 6 months after your quit date. At each 30 minutes clinic visit you will have your blood pressure, pulse and weight taken, you will complete several questionnaires and at you will provide a urine samples. You will be paid $25 per visit for your participation. If you are interested in participating, we will schedule you for an informational meeting where the study will be explained to in detail and you can ask questions before you start the study.
Contact: Joni Jensen, MPH, 612-627-4903 or jense010@umn.edu
Eating Disorder Research Study
Women ages 18 and older who struggle with binge eating and purging are needed for a research study providing free therapy. For more information about this University of Minnesota Study, please call 612-627-1991.
Studying Acid Reflux and Asthma (SARA Study)
People with asthma more often have something called 'silent acid reflux' that may make their asthma worse. The purpose of this study is to find out if treating people with asthma for silent acid reflux will improve their asthma. You may be eligible for SARA if you have asthma, you are taking a daily inhaled steroid such as Advair, you still have asthma symptoms, you do not take acid reflux medication, and you do not smoke. The study involves taking a pill that treats acid reflux twice a day, 9 visits over 6-8 months, test for acid reflux, and lung function testing. You would be compensated up to $600.
Contact: Call 612-626-4031 for more information.
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)
The purpose of this study is to determine the long-term safety and effectiveness of exercise training for individuals with congestive heart failure (CHF).
Contact: Kathy Duderstadt, 612-626-3427 or duder001@umn.edu
Diabetes Therapy to Improve Body Mass Index (BMI) and Lung Function in Cystic Fibrosis (CF)
The primary objective of this research is to determine whether treatment with either insulin or an oral diabetes agent that increases endogenous insulin secretion will improve body mass index (BMI) and pulmonary function in cystic fibrosis patients who have diabetes without fasting hyperglycemia.
Contact: Patricia J. Grover, RN, CCRC, grove026@umn.edu or 612-624-0135
Nociception in bulimia nervosa: Double-blind study of an investigational drug for bulimia nervosa
Women 18-50 who experience at least three episodes/week of binge eating followed by vomiting are needed for a free treatment study.
Contact: Patricia Faris, 612-626-4034
HER-2 Overexpressing Node Positive Breast Cancer
Phase III trial of investigational drugs followed by weekly investigational drug with or without an investigational drug as adjuvant treatment for women with HER-2 overexpressing node positive breast cancer.
Contact: Bruce Peterson MD, 612-624-5631
Postmenopausal Women with Locally Advanced or Metastatic Breast Cancer
A phase II randomized open-label study of letrozole in combination with two dose levels of an oral investigatonal drug, or letrozole alone, in postmenopausal women with locally advanced or metastatic breast cancer
Contact: Douglas Yee MD, 612-626-8487
Fairview Research Administration
Doctors are testing experimental medications and therapies for the treatment of Dysplasia
This study will determine if an investigational gene therapy can safely and effectively treat dysplasia. This study therapy is given as an injection. If you are between 13 and 25 years old, you may be able to take part in this research study. Since only certain types of dysplasia are being tested, you will need to talk to your doctor to see if you might be able to participate in this study.
Contact: Ashley Schempp, john3587@umn.edu or (612)626-5174
Recurrent or persistent Endometrial Cancer
Chemotherapy for recurrent or persistent endometrial caner.
Contact:Susann Mitchell, R.N., mitch016@umn.edu or 612-624-1919 or Ashley Schempp, john3587@umn.edu or (612) 626-5174
Metastatic Breast Cancer
The Ribbon 1 Study is seeking approximately 1000 patients over age 18 with metastatic breast cancer who have not previously received chemotherapy for this disease. Individuals who have received chemotherapy prior to being diagnosed with metastatic breast cancer may be eligible for the study as long as they have not been treated with chemotherapy since that diagnosis of metastatic breast cancer. The study will evaluate the safety and effectiveness of bevacizumab, an investigational compound, when combined with chemotherapy, compared to chemotherapy alone, in individuals who have not been previously treated with chemotherapy for metastatic breast cancer.
Contact: Fairview Clinical Trials Services by phone at (612) 672-5233 or email pbragdo1@fairview.org
Nutritional Intervention to Prevent Type1 Diabetes-Pilot Trial
This study on Nutritional Intervention to Prevent Type 1 Diabetes will help explain more about a dietary substance called DHA (docosahexaenoic acid). Who can Participate? -Pregnant women in their 3rd trimester can enroll if the expectated baby has a 1st degree relative with type 1 diabetes. -Newborns up to 5 months old if they have a 1st degree relative with type 1 diabetes.
Contact: Sarah Peterson 612-625-7931 pete5601@umn.edu or (612) 625-7931
Women with Nonresponsive or Recurrent Ovarian Cancer
The objective of this study is to assess the safety and efficacy of patupilone compared to pegylated liposomal doxorubicin. Additionally, this study will assess the ability of patupilone to extend the survival time and potential beneficial effects in women who have nonresponsive or recurrent ovarian, primary fallopian, or primary peritoneal cancer.
Contact: Deborah Biegert, RN, biege001@umn.edu or (612) 624-8647
Anorexia Nervosa Daily Diary Study
The University of Minnesota is seeking women ages 18 and over with symptoms of Anorexia Nervosa to take part in a study; this is not a treatment study. Eligible participants may be compensated up to $200.
Contact: Nora Sandager /Recruitment line 612-627-1991
Advanced Ovarian Cancer
The purpose of this research study is to determine if the combination of Yondelis and Doxil is better at improving overall survival over Doxil alone in subjects with relapsed advanced ovarian cancer. Study Inclusion Criteria includes: females, age 18 or older; epithelial ovarian cancer; prior treatment with only 1 platinum-based chemotherapy regimen; and recurrence of progression more than 6 months after the beginning of the initial line of platinum-based chemotherapy for ovarian cancer.
Contact: P Michael Nordberg, john3587@umn.edu or (612) 624-2701
Advanced Squamous Cell Carcinoma of the Cervix
Erlotinib (Tarceva) in Combination with Cisplatin as Radiosensitizing Agents in Women Receiving Radiation Therapy for Locally Advanced Squamous Cell Carcinoma of the Cervix; a Phase I Trial.
Coordinator: Suann Mitchell, mitch016@umn.edu or (612) 624-1919
Trametes Versicolor
Phase I Clincal Trial of Trametes versicolor in women with Breast Cancer.
Contact: Juliette Gay, gayxx001@umn.edu or (612) 625-2956
Advance Metastatic Breast Cancer
Allogeneic natural killer (NK) cells in patients with advanced metastatic breast cancer (MT2005-08)
Contact: Jeffrey Miller, mille011@umn.edu or 612-625-7409
High Risk or Relapsed Solid Breast Cancer
Dose Escalation of Total Marrow Irradiation (TMI) Delivered with Tomotherapy added to an Alkylator-Intense Conditioning Regimen for Patients with High Risk or Relapsed Solid Tumors
MORE INFO: Michael Verneris, verneris@umn.edu or 612-626-2961
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